Fig. 6: SFB− microbiota is sufficient for cPTH to expand intestinal and BM TNF+ T cells. | Nature Communications

Fig. 6: SFB− microbiota is sufficient for cPTH to expand intestinal and BM TNF+ T cells.

From: PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells

Fig. 6

a Relative frequency of PP TNF+ T cells, n = 9–10 mice per group. b Absolute number of BM TNF+ T cells, n = 9–10 mice per group. c, d SI and BM levels of Tnf transcripts. SFB+ TAC and JAX mice and SFB- JAX mice were treated with cPTH with antibiotics (Abx) or without antibiotics (No Abx) for 2 weeks, n = 5 mice per group. All data were normally distributed according to the Shapiro-Wilk normality test. Data were analyzed by two-way ANOVA and post hoc tests applying the Bonferroni correction for multiple comparisons. **p < 0.01, ***p < 0.001, and ****p < 0.0001 compared to the indicated group. Source data are provided as a Source Data file.

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