Fig. 9: Blockade of T cell egress from the intestine or of T cell influx in the BM prevent cPTH induced bone loss.

a Effects of cPTH on the number of PP and BM Th17 cells and BM Vβ14 + Th17 cells in SFB⁺ TAC mice treated with FTY720, n = 10 mice per group. b Effects of cPTH on the number of PP and BM TNF⁺ T cells in SFB⁺ TAC mice treated with FTY720, n = 10 mice per group. c Effects of cPTH on BV/TV, Tb.Th, serum CTX levels and serum osteocalcin levels in SFB⁺ TAC mice treated with FTY720, n = 10 mice per group. d Effects of cPTH on the number of PP and BM Th17 cells and BM Vβ14 + Th17 cells in SFB⁺ TAC mice treated with anti-CCL20 Ab, n = 10 mice per group. e Effects of cPTH on the number of PP and BM TNF⁺ T cells in SFB⁺ TAC mice treated with anti-CCL20 Ab, n = 10 mice per group. f Effects of cPTH on BV/TV, Tb.Th, serum CTX levels and serum osteocalcin levels in SFB⁺ TAC mice treated with anti-CCL20 Ab, n = 9–10 mice per group. g Effects of cPTH on the number of PP and BM Th17 cells and BM Vβ14 + Th17 cells in SFB⁺ JAX Cxcr3−/− mice and WT littermates, n = 9–10 mice per group. h Effects of cPTH on the number of PP and BM TNF⁺ T cells in SFB⁺ JAX Cxcr3−/− mice and WT littermates, n = 9–10 mice per group. i. Effects of cPTH on BV/TV, Tb.Th, serum CTX levels and serum osteocalcin levels in in SFB⁺ JAX Cxcr3−/− mice and WT littermates, n = 9–10 mice per group. Data are expressed as Mean ± SEM. All data were normally distributed according to the Shapiro-Wilk normality test and analyzed by two-way analysis-of-variance and post hoc tests applying the Bonferroni correction for multiple comparisons. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 compared to the indicated group. Source data are provided as a Source Data file.