Table 1 Subject characteristics.

From: Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

ADNI

CN-Aβ− (n = 28)

CN-Aβ+ (n = 32)

MCI- Aβ+ (n = 21)

 

p-value

Age

74.07 (6.82)

76.88 (5.86)

74.86 (7.57)

 

0.251

Sex (m/f)

12/16

12/20

11/10

 

0.564

Education (M/SD)

16.8 (1.94)

15.0 (4.56)

15.62 (2.92)

 

0.214

MMSE (M/SD)

29.25 (1.02)c

28.5 (2.13)c

26.53 (4.03)a,b

 

0.010

ADAS-global (M/SD)

7.93 (4.27)c

12.42 (7.16)c

17.61 (10.38)a,b

 

0.001

ApoE ε4 status (pos/neg)

5/23

19/13

14/7

 

0.002

Global AV45 SUVR(M/SD)

1.04 (0.04)b,c

1.33 (0.21)a

1.34 (0.13)a

 

<0.001

Mean tau-PET follow-up time in years (M/SD)

1.30 (0.52)

1.27 (0.46)

1.37 (0.57)

 

0.817

BioFINDER

CN-Aβ− (n = 16)

CN-Aβ+ (n = 16)

MCI- Aβ+ (n = 7)

AD dementia (n = 18)

 

Age

73.88 (5.32)

75.44 (6.09)

72.71 (6.63)

69.83 (10.48)

0.192

Sex (m/f)

10/6

6/10

2/5

11/7

0.245

Education (M/SD)

12.59 (4.06)

10.56 (3.22)

11.14 (2.67)

13.44 (3.26)

0.097

MMSE (M/SD)

29 (1.1)d

29.31 (1.08)d

25.57 (2.94)

22.06 (5.17)a,b

<0.001

ADAS-delayed recall (M/SD)

1.81 (1.47)c,d

2.31 (1.49)c,d

6.17 (2.4)

7.62 (2.45)a,b

<0.001

ApoE ε4 status (pos/neg)

0/16

10/6

4/3

11/7

<0.001

Global Flutemetamol SUVR

0.52 (0.03)b,c,d

0.77 (0.12)a,d

0.84 (0.14)a

0.97 (0.15)a,b

<0.001

Mean tau-PET follow-up time in years (M/SD)

2.03 (0.47)

1.91 (0.32)

1.82 (0.12)

1.97 (0.34)

0.484

  1. p-values were derived from ANOVA for continuous measures and from Chi-squared tests for categorical measures
  2. M male, f female, MMSE Mini-Mental State Exam, ADAS Alzheimer’s disease assessment scale, cognitive subscale
  3. Mean values significantly (p < 0.05) different from—
  4. aCN-Aβ−
  5. bCN-Aβ+
  6. cMCI-Aβ+
  7. dAD dementia
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