Fig. 4: TDP-43 regulates expression of BTN and XOR.
From: TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh
a Heatmap of differentially expressed genes from mammary glands between wild-type (WT, n = 3) and Tardbp−/− (KO, n = 4) mice at lactation day 1 (L1). Colors of bars represent normalized and scaled expression levels (red, white, and blue correspond to highest, middle, and lowest values, respectively). b Quantitative real-time PCR (qRT-PCR) analysis of Btn1a1 expression in WT and Tardbp−/− mice at L1 (n = 5 mice) and L10 (n = 4 mice). c Quantitative real-time PCR analysis of Xdh expression in WT and Tardbp−/− mice at L1 (n = 5 mice) and L10 (n = 5 mice). d, e Western blot showing expression of BTN and XOR in MECs isolated at pregnancy day 17.5 (d) and L1 (e) from WT and Tardbp−/− mice. f Protein levels of BTN and XOR in differentiated HC11 cell line upon Tardbp knockdown. Data are means ± SD. Unpaired t test was used to evaluate statistical significance. *P < 0.05; **P < 0.01. Source data are provided as a Source Data file.
