Fig. 1: Identification of transcription factors associated with azole tolerance in A. fumigatus.
From: The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus
a Relative growth fitness of the 484 constructed TFKO mutants in MIC (0.5 mg/L) and sub-MIC (0.06 and 0.12 mg/L) levels of itraconazole. Each dot represents the mean of three replicate experiments. The TFKOs which exhibited significant fitness defects (fitness less than −4 for sub-MIC, and more than 1.5 for MIC condition) are indicated by coloured circles. b, c Heatmaps showing drug susceptibility profiles of the screened TFKO mutants to different antifungal drugs. Susceptibility assays were performed in triplicate, where optical density readings of fungal growth were standardised to no-drug control wells and shown as a relative growth values. Source data are provided as a Source Data file.
