Fig. 7: Human SPHK1 expression correlates with immune suppressive factors. | Nature Communications

Fig. 7: Human SPHK1 expression correlates with immune suppressive factors.

From: Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1

Fig. 7

a Heat map for a selected list of genes indicative of immune suppression exhibiting low (20th percentile) and high (80th percentile) SPHK1 expression in melanoma samples using the TCGA cohort. Red indicates high expression and blue indicates low expression relative to the mean expression of the gene across all samples (n = 136). b Correlations between SPHK1 expression (log2(x + 1) transformed RSEM normalized count) and genes indicative of immune suppression using non-parametric Spearman’s test (n = 342).

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