Fig. 7: iNIRS deconstructs DWS/DCS during a hypercapnic challenge in the mouse brain.
From: Time-of-flight resolved light field fluctuations reveal deep human tissue physiology
By accounting for absorption changes (a), conveniently also measured by iNIRS, and fitting early time lags in DWS/DCS, agreement of DWS/DCS blood flow indices with iNIRS is improved (b–c). However, even when such best practices are followed in DWS/DCS (black in d, the accuracy of DWS/DCS can still be significantly improved either by integrating just the iNIRS fast component (red in d) or the iNIRS early time lag single exponential fit (cyan in d). This is likely because the slow component (magenta), though intravascular in origin, is not described by conventional DWS/DCS theory (Supplementary Fig. 6).
