Fig. 3: Structural comparison of the L and P proteins.
From: Cryo-EM structure of the respiratory syncytial virus RNA polymerase
a Superimposition of the RNA dependent RNA polymerase (RdRp) and capping (Cap) domains of the L protein from RSV (this work) and VSV (PDB: 5A22). RSV L is colored the same as Fig. 2a, and VSV L is colored in gray. b The cartoon representation of the RSV L and P. The missing domains are colored in gray. c Overview of the RdRp domain. d Magnified view showing the core residues (GDN, magenta for RSV, orange for VSV) and the missing supporting helix (orange, VSV L) in the RdRp domain. e Overview of the Cap domain. f Magnified view showing the core residues (HR, magenta for RSV, orange for VSV) in the Cap domain. The priming-loop-like element of the RSV L and the VSV L is highlighted in magenta and orange, respectively. A major shift (~37 Å) from the tip of the priming-loop-like element is shown as the black arrow. g Superimposition of the oligomerization domain of P (POD) from RSV (this work) and HMPV (PDB: 4BXT). The HMPV P is in gold.
