Fig. 3: Hominin-specific gains emerge postnatally. | Nature Communications

Fig. 3: Hominin-specific gains emerge postnatally.

From: Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients

Fig. 3

a Box plots showing normalized H3K27ac enrichment in PFC or CB samples across different developmental timepoints for hominin-specific gains, stable GREs and all primate GREs. Dissimilarities between distributions were calculated using a Student’s t test. b Box plots showing normalized gene expression values of genes linked to hominin-specific PFC gains across developmental time, for both human and rhesus macaque. Dissimilarities between distributions were calculated using a Student’s t test. c Box plots showing normalized gene expression values in the white matter tissue of different primates for genes linked to hominin-specific PFC changes. Dissimilarities between distributions were calculated using a Student’s t test. d Gene-ontology analysis using GREAT for hominin-specific PFC gains. P values represent significance of enrichment for stated biological process. Bottom and top of all box plots are the first and third quartile. The line within the boxes represents the median and whiskers denote interval within 1.5× the interquartile range from the median, outliers are depicted as points.

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