Table 1 Concentrations (nM) of taccalonolide probes that cause a 50% decrease in the proliferation (GI50) of HeLa or SK-OV-3 cells.

From: Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach

Compound

HeLa

SK-OV-3

2

8.5 ± 0.1

6.2 ± 1.4

3

2,100 ± 20026

ND

4

>20,000

>20,000

5

12,200 ± 1,700

11,800 ± 2,100

6

8,300 ± 600

10,800 ± 1,600

7

>20,000

>20,000

8

1,500 ± 400

4,500 ± 900a

9

740 ± 60

970 ± 60

10

>20,000

>20,000

11

31 ± 2

47 ± 8a

12

3,000 ± 200a

7,200 ± 400

  1. adata from 4 independent experiments.
  2. GI50 values were obtained from three independent experiments (unless otherwise noted) each performed in triplicate and presented as mean ± SEM. Source data are provided as a Source Data file.
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