Fig. 1: Recombinant arginase 1 (recArg1) improves outcome in diverse murine arthritis models and arginase 1 is elevated in erosive RA patients.
From: Environmental arginine controls multinuclear giant cell metabolism and formation
a, b Paw histology, osteoclast numbers per hind paw (N. Oc), total scores, weight and histology inflammation area of mice suffering from serum transfer arthritis (a K/BxN, NaCl n = 12, recArg1 n = 13 animals) or the hTNFtg/+ mouse model (b NaCl n = 13, recArg1 n = 14 animals). Scale bar represents 1 mm. c Ctsk IVIS and quantification, total scores and weights of mice suffering from collagen-induced arthritis (CIA, NaCl n = 13, recArg1 n = 14 animals, Ctsk IVIS n = 6 animals). d RecArg1 depletes serum arginine; K/BxN (n = 13 animals per group), CIA (NaCl n = 13, recArg1 n = 14 animals). NaCl in a–d represents saline vehicle control group. e Serum crosslaps in the indicated patient groups (erosive RA n = 30, non-erosive RA n = 29 patients). f Serum arginine levels of all patient groups (healthy n = 19, erosive RA n = 29, non-erosive RA n = 30 patients). g Arginase 1 levels in all patient groups and correlation between arginase 1 and erosion score of patients suffering from erosive RA (healthy n = 19, erosive RA n = 29, non-erosive RA n = 30 patients). Data are mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, unpaired t-test (a–c, e–g), one-way ANOVA (d) and two-way ANOVA post-hoc pairwise comparisons with Bonferroni correction (a–c), linear regression (g). Source data are provided as a Source Data file.
