Fig. 2: CAAs in primary and metastatic samples shape tumour evolution.
From: Chromosome arm aneuploidies shape tumour evolution and drug response
a Violin plots comparing CAA burden in primary and metastatic solid tumours. Medians and interquartile ranges are shown. LN, lymph node; Met, metastases at any metastatic site. P value: Mann–Whitney U test. b Heatmap of the frequency differential in metastatic disease relative to primary cancers. Numbers in tiles refer to q values, i.e., FDR-adjusted p values of Fisher’s exact tests. Empty tiles, not significant (q > 0.05); 1, q < 0.05; 2, q < 10−2; 3, q < 10−3, etc. c Heatmap as in b, but per metastatic site. Yellow boxes highlight a degree of specificity. The black/yellow heatmap below shows the frequencies of indicated CAAs in primary brain cancers. d Stochastic tumour evolution model. The network models the order in which CAAs are acquired during breast cancer development. Nodes represent CAAs and their sizes are proportional to CAA frequencies. Edges represent estimated transition probabilities and their thicknesses are proportional to the probabilities. Note that the edges are directed, from left to right. Source data are provided as a Source Data file.
