Fig. 5: Summary of CAA-informed survival outcome, with negligible impact of whole-genome doubling.
From: Chromosome arm aneuploidies shape tumour evolution and drug response
a Sunburst charts for disease-free and overall survival. In total, n = 97 and n = 63 statistically significant individual CAAs (‘1 CAA’) or CAA combinations (‘2 CAAs’) were identified. Inner rings indicate fractions of 1 CAA and 2 CAAs. Outer rings indicate how many of the two individually cooccurring CAAs significantly predict patient survival outcome. b Sunburst chart showing number of patients analysed (n = 6,977) and fractions for whom CAAs predict good (green, left) or poor prognosis (red, right) based on individual (‘1 CAA’) or co-occurring CAAs (‘2 CAAs’). c Left: Ring pie charts showing the number of cancer types for which whole-genome doubling (WGD) significantly affects poor overall or disease-free survival in univariate Cox proportional hazard analyses. Right: Ring pie charts depicting the multivariate Cox proportional hazard p values of the 44 single or co-occurring CAAs for which WGD showed p values < 0.05 in univariate analyses (left). These multivariate analyses included WGD as a covariate. Source data are provided as a Source Data file.
