Fig. 5: Synthetic application.

a Functionalization of natural products, b post-functionalization of γ-alkynyl nitrile and γ-alkynyl ketone. [a] Ni(COD)2 (5 mol%), PBu3 (10 mol%), BPh3 (20 mol%), toluene, 50 °C, 24 h. [b] tBuOK, THF, 0 °C.
a Functionalization of natural products, b post-functionalization of γ-alkynyl nitrile and γ-alkynyl ketone. [a] Ni(COD)2 (5 mol%), PBu3 (10 mol%), BPh3 (20 mol%), toluene, 50 °C, 24 h. [b] tBuOK, THF, 0 °C.