Fig. 5: Genetically distinct iHGG models present different patterns of longitudinal evolution. | Nature Communications

Fig. 5: Genetically distinct iHGG models present different patterns of longitudinal evolution.

From: Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells

Fig. 5

Primary and secondary spheres of PTEN−/−;NF1−/− (a) and TP53−/−;PDGFRAΔ8–9 (b). UMAP plot color-coded by samples (top left) or by Louvain clustering (top right). Sample distribution found in each Louvain cluster, color-coded by sample identity (bottom left) and Louvain cluster distribution per sample, color-coded by cluster identity (bottom right). Clustered heatmaps of enriched GO terms extracted from differentially expressed genes of each Louvain cluster in PTEN−/−;NF1−/− (c) and TP53−/−;PDGFRAΔ8–9 (d). Color scale represents statistical significance. Gray color indicates a lack of significance.

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