Fig. 1: Therapeutic potential of antimiR-132 treatment.
From: Preclinical development of a miR-132 inhibitor for heart failure treatment
a Study outline of antimiR-132 application (20 mg/kg, i.p.) to miR-212/132 transgenic (TG) mice compared to placebo treatment (0.9% NaCl solution) and wildtype (WT) mice. b Functional miR-132 level. c MiR-132 target gene expression (Forkhead Box Protein O3, Foxo3). d Representative images of the parasternal long axis (PLAX) view of the left ventricle (LV) (scale bar = 2 mm) and heart weight (HW) vs. Tibia length ratio of mice. e Echocardiographic evaluation of ejection fraction and end-systolic volume. WT: n = 8, TG + NaCl: n = 7, TG + antimiR-132: n = 6. Data are mean ± s.e.m; **P < 0.01; unpaired two-sided Mann–Whitney U test.
