Fig. 3: Pharmacokinetic properties of antimiR-132.
From: Preclinical development of a miR-132 inhibitor for heart failure treatment
a Cardiac tissue levels of antimiR-132 in healthy pigs 48 h post treatment for different dose levels (Control: None; Low = 1 mg/kg, Medium = 5 mg/kg and High = 10 mg/kg antimiR-132, n = 3 respectively) by intravenous (IV) or intracoronary (IC) application. b Functional cardiac tissue level of miR-132 in healthy pigs 48 h post treatment. c Correlation between antimiR-132 and miR-132 cardiac tissue levels in healthy pigs 48 h post treatment. d Time course of cardiac tissue levels of antimiR-132 in healthy pigs at different timepoints post treatment (5 mg/kg antimiR-132, IV, n = 3 respectively). e Plasma levels of circulating antimiR-132 in healthy pigs at different timepoints post treatment (5 mg/kg antimiR-132, IV, n = 3 respectively). Data are mean ± s.e.m; *P < 0.05, **P < 0.01; Kruskal–Wallis test with Dunn’s multiple comparison (Control vs. treatment groups) and linear regression using non‐parametric Spearman correlation.
