Fig. 5: Maximum signature activity changes in PCAWG samples.
From: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
The red line shows the threshold of 5%, above which we consider changes to be significant. a Changes on random orders of mutations where we do not expect to see change in activities. b activity changes in TrackSig trajectories across all samples (on mutations sorted by CCF). Frequency axis shows the number of samples where we observe the certain activity change.
