Table 1 Demographics and biomarkers data from the different cohorts.

From: Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia

 

n

Age

Sex (f/m)

t-Tau (pg/mL)

p-Tau (pg/mL)

Amyloid β42 (pg/mL)

Lipocalin 2 (pg/mL)

Cohort 1

ND

73

67 ± 10

40/33

232 ± 207

40 ± 11

719 ± 351

771 ± 347

AD

47

67 ± 10

26/21

591 ± 435

90 ± 51

449 ± 207

691 ± 247

VaD

27

72 ± 8

17/10

386 ± 445

44 ± 15

779 ± 348

2233 ± 1326

MD

31

74 ± 10

25/6

444 ± 272

76 ± 54

437 ± 206

1565 ± 833

LBD

36

69 ± 11

18/18

385 ± 301

56 ± 42

513 ± 292

917 ± 398

FTD

21

65 ± 12

8/13

373 ± 370

57 ± 21

665 ± 251

762 ± 331

CJD

54

68 ± 10

27/27

5936 ± 5914

61 ± 18

635 ± 324

1037 ± 661

SVDND

20

63 ± 14

9/11

181 ± 135

34 ± 16

787 ± 229

753 ± 300

VCIND

7

66 ± 9

2/5

177 ± 59

48 ± 12

1114 ± 220

946 ± 366

Cohort 2

ND

24

64 ± 8

12/12

168 ± 74

35 ± 14

913 ± 409

713 ± 232

AD

15

68 ± 6

6/9

602 ± 336

71 ± 27

417 ± 95

660 ± 182

VaD

10

69 ± 10

3/7

330 ± 236

38 ± 13

768 ± 188

1440 ± 979

Cohort 3

ND

15

67 ± 13

7/8

193 ± 57

33 ± 9

684 ± 123

753 ± 386

AD

27

72 ± 6

16/11

647 ± 307

88 ± 29

435 ± 81

709 ± 236

VaD

16

74 ± 6

10/6

402 ± 300

55 ± 23

501 ± 134

1381 ± 953

Cohort 4

AD

28

72 ± 10

21/7

595 ± 234

86 ± 25

634 ± 228

634 ± 198

SVDND

3

71 ± 8

1/2

135 ± 37

27 ± 9

953 ± 55

613 ± 258

VCIND

8

67 ± 5

3/5

174 ± 45

38 ± 12

869 ± 328

845 ± 277

VaD

10

76 ± 6

3/7

248 ± 66

43 ± 11

932 ± 221

1131 ± 481

  1. Number of cases (n), age (mean ± standard deviation), sex (female/male), CSF biomarkers total-Tau, p-Tau and amyloid beta 42 and CSF LCN2 (mean ± standard deviation in pg/mL) are indicated.
  2. ND non-primarily neurodegenerative and non-ischemic neuropsychiatric diseases, AD Alzheimer’s disease, VaD vascular dementia, MD mixed dementia, LBD Lewy body dementia, FTD frontotemporal dementia, CJD sporadic Creutzfeldt-Jakob disease, SVDND small vessel disease no dementia, VCIND vascular cognitive impairment no dementia.
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