Fig. 7: H3R2me2a is associated with tumor progression.
From: PRMT6-mediated H3R2me2a guides Aurora B to chromosome arms for proper chromosome segregation
a, b Clinicopathologic characteristics of the TMA from human breast cancer patient tissues (n = 405) in the high (staining score, 2–3) and low (staining score, 0–1) groups were quantified and plotted. c–e Immunohistochemical staining of H3S10ph in 410 human breast cancer patient tissues and normal adjacent tissues. The H3S10ph intensity in metaphase cells was quantified and plotted (n = 327 metaphase cells for low-H3R2me2a and n = 627 metaphase cells for high-H3R2me2a tissue in TNBC; n = 245 metaphase cells for low-H3R2me2a and n = 366 metaphase cells for high-H3R2me2a tissue in non-TNBC). The arrows point to metaphase cells. Error bar, SEM. f Proposed model of the crosstalk between histone marks for the CPC positioning and chromosome condensation. Scale bars, 50 μm. Source data are provided as a Source Data file. (Student’s t-test *p < 0.01).
