Fig. 1: Chalcone synthase (CHS)-catalyzed formation of THC and other polyketides. | Nature Communications

Fig. 1: Chalcone synthase (CHS)-catalyzed formation of THC and other polyketides.

From: A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity

Fig. 1

The CHS-catalyzed process (steps a through f) is presented in a gray background. One of the CHS substrates, p-coumaroyl-CoA, is derived from L-phenylalanine via the general phenylpropanoid pathway and serves as a precursor of lignin, cuticle biopolymers, and other phenylpropanoids in plants. A diffusible intermediate of the CHS-catalyzed reaction may serve as a substrate of chalcone reductase in deoxyflavonoid biosynthesis10. Additionally, THC serves as a precursor of aurones, whereas naringenin serves as a precursor of other flavonoids6,11. CL, 4-coumaric acid:CoA ligase.

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