Fig. 1: APOBEC3B expression enhances tumor escape but sensitizes tumors to immune checkpoint blockade therapy. | Nature Communications

Fig. 1: APOBEC3B expression enhances tumor escape but sensitizes tumors to immune checkpoint blockade therapy.

From: APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy

Fig. 1

a On day 0, 2 × 105 B16TK cells expressing either APOBEC3BINACTIVE or APOBEC3BACTIVE were subcutaneously implanted into the right flank of C57Bl/6 mice. Two 5-day courses of GCV therapy (50 mg/kg i.p.) were administered from days 7 to 11, and 14 to 18, followed by anti-CTLA4 antibody or control IgG (5 mg/kg i.p.) on days 21, 23, and 25. b, c Mice were treated according to the regimen in (a) (n = 7 mice/group) tumor volumes were measured three times per week (c) and sacrificed when tumors grew above 1 cm in length or width. Representative of three separate experiments. Groups were compared using a Log-Rank test with Holm–Bonferroni correction for multiple comparisons.

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