Fig. 4: Variation in reticulocyte invasion inhibition by human antibodies is not dependent on the polymorphism of the Duffy receptor of reticulocytes. | Nature Communications

Fig. 4: Variation in reticulocyte invasion inhibition by human antibodies is not dependent on the polymorphism of the Duffy receptor of reticulocytes.

From: Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity

Fig. 4

a Similar invasion percent of parasites in FyA/FyB and FyA/FyA reticulocytes in absence of antibodies (NS: non-significant, Mann-Whitney U = 108, P = 0.1794). Each dot represents the invasion percent of a different clinical isolate with 1 to 3 technical replicates per isolate. Mean ± SEM. b Similar invasion percent in FyA/FyA reticulocytes between single and multi copies pvdbp parasites in absence of antibodies (Mann-Whitney U = 47, P = 0.2768). Each dot represents the invasion percent of a different clinical isolate with 1 to 3 technical replicates per isolate. Mean ± SEM. c The pvdbp copy number of parasites drives variation in inhibition of invasion in FyA/FyA reticulocytes by human antibodies. Pooled invasion percent data in presence of 100 μg ml−1 of humabs (black 099100, blue 053054, orange 092096) of isolates with one copy (CN1), two copies (CN2) or three copies (CN3) of pvdbp. ANOVA F (4, 51) = 93.91, P < 0.0001, Tukey’s post-hoc tests, *P < 0.05, ****P < 0.0001. Each dot represents the invasion percent of a different clinical isolate with 1 to 3 technical replicates per isolate. Mean ± SEM. Source data are provided as a Source Data file.

Back to article page