Fig. 3: Substrates scope for trifluoromethoxylation of simple alkyl halides.
From: Nucleophilic trifluoromethoxylation of alkyl halides without silver
Standard reaction conditions: alkyl halide (1.0 equiv.), Cs2CO3 (3.5 equiv.), TFBO (5.0 equiv.), DMA, 70 °C, N2. #50 °C. †90 °C. ‡Cs2CO3 (4.0 equiv.), TFBO (6.0 equiv.), TBAI (3.0 equiv.), HMPA. §Cs2CO3 (4.0 equiv.), TFBO (6.0 equiv.), TBAI (0.2 equiv.), HMPA.*Yields were determined by 19F NMR with benzotrifluoride as a standard.
