Fig. 4: Genomic differences between primary tumors and thrombi.

a Anatomical diagram of patients with thrombus. b The top bar plots display the numbers of shared or specific non-silent mutations between primary tumors and thrombi from 42 ccRCC-TT patients. The inset plot shows the distribution of heterogeneity between the primary tumors and thrombi. The bottom bar plots show the proportions of shared or specific mutations. c The contributions of six substitution patterns in primary tumors and thrombi. d The top 15 mutated genes in primary tumors and thrombi. The box plot displays the first and third quartiles (top and bottom of the boxes), the median (band inside the boxes), and the lowest and highest point within 1.5 times the interquartile range of the lower and higher quartile (whiskers). e Volcano plot of differentially expressed genes between primary tumors and thrombi with a threshold fold-change of 2 and p < 0.01. f The GSEA results revealed that the set of genes expressed in the thrombi were enriched in the cell cycle pathway, immunological pathway, and change of extracellular matrix and structure pathway. The source data underlying Fig.  4b–d are provided as a Source Data file.