Fig. 5: A de novo remodeled PVT1 enhancer in BETi-resistant leukemia cells. | Nature Communications

Fig. 5: A de novo remodeled PVT1 enhancer in BETi-resistant leukemia cells.

From: A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells

Fig. 5

a Differential enrichment of H3K27ac at all identified MYC enhancers between parental (sensitive) and BETi-resistant murine AF9 AML cells. Red arrow: The genomic region within Pvt1 locus at the top differential enriched regions between parental and BETi-resistant murine AF9 AML cells. b Genome browser views of H3K27ac enrichment in the PVT1 locus (left) and BENC enhancers (E1–E5, right) of MYC in the indicated leukemia cell lines with relatively high (red) or low (blue) IC50 values of BETi. Green highlighted regions represented MYC enhancers. c Genome browser view of H3K27ac enrichment at Myc Pvt1 locus (top) and BENC enhancers (E1–E5, bottom) in BETi-sensitive (Vehicle, blue) and resistant (red) murine AF9 AML cells. Green highlighted regions were identified MYC enhancers. d Genome browser views of H3K27ac and ATAC-seq signals of MYC PVT1 enhancers in K562 (red) and THP1 (blue) cells. Green highlighted regions were identified MYC enhancers.

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