Fig. 2: TDP2 deficiency increases thymic cancer predisposition of Atm−/− but not of Tpr53−/− mice. | Nature Communications

Fig. 2: TDP2 deficiency increases thymic cancer predisposition of Atm−/− but not of Tpr53−/− mice.

From: Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

Fig. 2

a, b Kaplan–Meier survival curve (a) and cumulative occurrence (b) of thymic tumours during the 1st year of life of at least 20 mice with the indicated Tdp2 and Atm genotypes. n = 21 (Tdp2+/+ Atm+/+), n = 23 (Tdp2−/− Atm+/+), n = 23 (Tdp2+/+ Atm−/−), n = 21 (Tdp2−/− Atm−/−). Tdp2+ indicates both Tdp2+/+ and Tdp2+/− genotypes. Statistical significance by two-sided Wilcoxon test is indicated. c Percentage of tumours composed by immature CD4+ CD8+ double positive, or CD4+/CD8+ single positive lymphocytes in the indicated genotypes. Thymocytes were selected by size and complexity prior classification by high or low CD4 and CD8 markers (see Supplementary Fig. 1a for gating strategy). d Median life-span of Tdp2+/+ Atm−/− and Tdp2−/− Atm−/− mice affected by a thymic tumour (n = 11 and n = 16 for Tdp2+/+ Atm−/− and Tdp2−/− Atm−/− mice respectively). e Kaplan–Meier survival curve and f cumulative incidence of thymic tumours of the indicated Tdp2 and Trp53 genotypes (n = 16 for Tdp2+/+ and n = 22 for Tdp2−/−).

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