Fig. 3: Tdp2−/−Atm−/− and Atm−/− thymic malignancies display similar genome rearrangements. | Nature Communications

Fig. 3: Tdp2−/−Atm−/− and Atm−/− thymic malignancies display similar genome rearrangements.

From: Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

Fig. 3

a Merged CGH analysis of Tdp2+/+Atm−/− (three mice, top) and Tdp2−/−Atm−/− (six mice, bottom) thymic lymphomas. DNA from each tumour sample was hybridized and analysed using kidney DNA from the same mouse as a control. Average amplification (red) or deletion (blue) score (Log2 tumour/kidney ratio) is shown. Significant copy number variations are defined by −0.66>Log2 tumour/kidney>0.66 (dashed lines). The location of relevant loci in Atm−/− thymic tumours is indicated. b Table summarising the number of mice of each genotype displaying copy number variation at the indicated locus of interest. Amp(Tcra/d): amplification upstream of Tcra/d; Del(12): deletion of the telomeric region of chromosome 12 covering Bcl11b; Del(Tcrb): deletion at the Tcrb locus; Amp(15): trisomy of chromosome 15; Del(Pten): deletion at the Pten locus; Amp(Notch1): duplication at the Notch1 locus.

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