Fig. 2: Structural comparison.

a, b Crystal structures of Siwi (PDB: 5GUH) a and hAgo2 (PDB: 4W5N) b. c, d Superimposition of Piwi on Siwi (blue) c and hAgo2 (red) d, based on their PIWI domains. Note that the Piwi PAZ domain is not well resolved in the density map, suggesting its flexibility. e–g N domain interfaces of Piwi e, Siwi f, and hAgo2 g.