Fig. 3: Interrogation of the RALY cistrome and chromatin dynamics enriches for promoter binding and metabolic coregulators. | Nature Communications

Fig. 3: Interrogation of the RALY cistrome and chromatin dynamics enriches for promoter binding and metabolic coregulators.

From: Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice

Fig. 3

a Heat map of reproducible counts centered around a gene transcription start site for RALY ChIP-seq samples in hepa1-6 cells (n = 4 per group). b ChIP fragment depth enrichment for RALY across samples. c Pi chart showing the binding pattern of RALY according to the location of a given peak. d Representative RALY ChIP-seq profiles at Srebf2 and Klf6 loci. e Motif analysis surrounding called peaks from RALY ChIP-seq in hepa1-6 cells. f Schematic of ATAC-seq workflow. g Metagene representation of the mean ATAC-seq signal. ATAC-seq was performed from mice liver with Raly f/f L-Cre+ or Cre− (n = 4 per group). h, i Heat map shows the differential enrichment of ATAC peaks of Cre− or Cre+ livers and Gene ontology analysis. j Representative ATAC-seq heat map in liver with Raly f/f L-Cre+ or Cre− at the Srebf2 locus. k Motif analysis showing top enriched factors at differentially regulated sites from Raly f/f L-Cre+ or L-Cre− liver.

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