Fig. 1: FPR2-Gi coupling and overall structure of the complex. | Nature Communications

Fig. 1: FPR2-Gi coupling and overall structure of the complex.

From: Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling

Fig. 1

a 35S-GTPγS binding assays using FPR2- and C5aR-expressing cell membranes and purified Gi heterotrimer with increasing concentrations of WKYMVm (WKY for short in all figures). n = 3, data are mean ± s.e.m. Source data are provided as a Source Data file. b 3D cryo-EM density map and overall structure of FPR2-Gi with WKYMVm and scFv16. Cholesterol molecules are shown as pink sticks. Cryo-EM map is colored according to different subunits. The density of WKYMVm is shown in the upper middle.

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