Fig. 3: Chemoselective removal of cyanosulfurylides. | Nature Communications

Fig. 3: Chemoselective removal of cyanosulfurylides.

From: Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups

Fig. 3

In solution removal of cyanosulfurylide in the presence of oxidation-sensitive residues including tryptophan and StBu protected cysteine. NCS was titrated to the solution until full conversion was indicated by HPLC and mass spectrometry. Reaction went to completion within 5 min at 25 °C without any side-product being observed by HPLC and mass spectroscopy.

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