Fig. 5: Mouse bone marrow case study.
From: Trajectory-based differential expression analysis for single-cell sequencing data
a Two-dimensional representation of a subset of the data using independent components analysis (ICA). The myeloid trajectory inferred by slingshot is displayed. b Two-dimensional representation of a subset of the data using UMAP. The myeloid trajectory inferred by slingshot is displayed. The UMAP dimensionality reduction method better captures the smooth differentiation process than ICA. c Estimated smoothers for the top six genes identified by the tradeSeq patternTest procedure on the trajectory from (b). d Six clusters for the top 500 genes with different expression patterns between the two lineages (as identified by patternTest from tradeSeq).
