Fig. 2: Deleterious mutations segregating in Alpine and Iberian ibex.
From: Purging of highly deleterious mutations through severe bottlenecks in Alpine ibex
a Population sampling locations of Iberian ibex (left, gray circles) and Alpine ibex (right, colored circles). Each filled circle represents a population. Circles with a black outline indicate the first three reintroduced populations in Switzerland that were used for all subsequent population reintroductions of Alpine ibex. Colors associate founder and descendant populations (see also Fig. 3a). b Site frequency spectrum for neutral (modifier), mildly (moderate impact) and highly deleterious (high impact) mutations for Alpine ibex. Alternative allele counts > 10 are shown as mean counts per interval. c Site frequency spectrum for Iberian ibex. d Site frequency spectrum for Alpine ibex downsampled to four individuals matching the sample size of Iberian ibex (100 replicates). See Figure S11 for additional downsampling and jack-knifing analyses of data presented in (b–d). e Rxy analysis contrasting Iberian with Alpine ibex across the spectrum of impact categories. Rxy < 1 indicates a relative frequency deficit of the corresponding category in Alpine ibex compared to Iberian ibex. Rxy distributions are based on jack-knifing across chromosomes. All pairwise comparisons were significant except low vs. moderate (Tukey test, p < 0.0001). f Individual homozygote counts per impact category for Iberian (light green) and Alpine ibex (dark green). Boxplots elements are defined as in Fig. 1. Source data are provided as a Source Data file.
