Fig. 5: Homology-based inference of the impact of highly deleterious mutations.
From: Purging of highly deleterious mutations through severe bottlenecks in Alpine ibex
The localization of protein family (PFAM) domains are highlighted in dark. Red dots indicate the relative position of a highly deleterious mutation segregating in Alpine ibex. The frequencies of highly deleterious mutations are summarized for Iberian ibex and three groups of Alpine ibex. Allele frequencies are shown as boxplots per group representing the outcome of downsampling to the smallest group (Alpi Marittime, n = 3) based on 100 replicates. The frequencies of highly deleterious mutations tend to be higher in Alpine ibex because mutation ascertainment was performed in this species. Box plot elements are defined as in Fig. 1. Source data are provided as a Source Data file.
