Fig. 5: Changes in rCBF associated with systemic OT are predicted plasma OT post-dosing. | Nature Communications

Fig. 5: Changes in rCBF associated with systemic OT are predicted plasma OT post-dosing.

From: Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

Fig. 5

To investigate if concomitant increases in peripheral OT were related to treatment-induced changes in rCBF, we extracted data from each significant rCBF cluster in the paired sample t-tests and calculated Spearman correlation coefficients between these contrasts estimates and the areas under the curve (AUCs) reflecting individual differences in treatment-induced OT plasma concentrations for the corresponding method of administration. In panel a, we present decreases in rCBF after spray OT at 24–32 min post-dosing; in panel b, decreases in rCBF after spray OT at 87–95 min post-dosing; in panel c, decreases in rCBF after intravenous OT at 24–32 min post-dosing; and in panel d, decreases in rCBF after intravenous OT at 87–95 min post-dosing. r corresponds to the Spearman coefficient of correlation. Statistical significance was set to p < 0.05 (two-tailed). Source data are provided as a Source Data file.

Back to article page