Table 2 Paired t-contrasts comparing standard spray OT to placebo/saline.

From: Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

Cluster description

Hemisphere

K

Pfwe

Peak coordinates

Description

x

y

z

Spray > placebo (15–23 min)

 Cluster 1: superior/middle frontal gyrus, supplementary motor area, precentral gyrus

Left

1500

<0.001

−24

24

64

Left superior/middle frontal gyrus

−26

28

46

−24

16

68

Spray < placebo (24–32 min)

 Cluster 2: parahipocampal gyrus, temporal pole, amygdala, insula, hippocampus

Left

1295

<0.001

−34

8

−20

Left temporal pole

−16

−6

−34

Left enthorinal area

−18

−6

−26

Left enthorinal area

Spray > placebo (35–43 min)

 Cluster 3: middle and inferior frontal gyrus, precentral gyrus

Left

999

<0.001

−42

40

34

Left middle frontal gyrus

−54

20

38

−42

46

28

Spray > placebo (87–95 min)

 Cluster 4: superior and middle temporal gyrus, insula, postcentral gyrus

Left

1848

<0.001

−56

−46

2

Left middle/superior temporal gyrus

−66

−20

30

Left postcentral/supramarginal gyrus

−60

−46

−8

Left middle temporal gyrus

 Cluster 5: superior and inferior parietal lobe, postcentral and precentral gyrus, precuneus

Left

1315

<0.001

−18

−54

52

Left superior parietal lobe

−36

−44

52

Left superior parietal lobe/supramarginal gyrus

−24

−20

66

Left precentral gyrus

Spray < placebo (87–95 min)

 Cluster 6: anterior cingulate, right superior and medial frontal gyrus

Right

1350

<0.001

24

46

12

Right middle frontal gyrus

Right

16

46

12

Right superior frontal gyrus

Bilateral

−2

36

28

Anterior cingulate gyrus

 Cluster 7: brainstem and cerebellum*

Bilateral

591

0.01

6

−40

−56

Brainstem

Right

14

−48

−56

Right cerebellum

Bilateral

6

−38

−32

Brainstem

  1. We compared CBF maps following standard spray OT and placebo administration using paired t-contrasts at each time-interval (to capture the direction of potential rCBF changes), controlling for global CBF as a nuisance variable. We conducted cluster-level inference, reporting clusters significant at p < 0.05 FWE-corrected (cluster-forming threshold: p < 0.005, uncorrected). Clusters that do not survive correction for multiple testing following adjustment of the P-value using Bonferroni correction for the 24 paired-t-tests performed are denoted by an asterisk (*) (Padjusted = 0.05/24 = 0.002).
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