Table 1 Kinetic constants for hydrolysis of ACE2 substrate by B38-CAP and IC50 of MLN-4760, an ACE2 inhibitor.
From: B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction
Km (μM) | kcat (s−1) | kcat/Km (s−1 μM−1) | IC50 (pM) | |
|---|---|---|---|---|
B38-CAP | 23.3 ± 1.70 | 188 ± 6.87 | 8.07 ± 0.295 | 710 ± 173 |
ACE2 | 23.8 ± 1.91 | 168 ± 6.18 | 7.08 ± 0.260 | 340 ± 50.1 |
