Table 2 Hydrolysis of ACE2-substrate peptides by B38-CAP.
From: B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction
Substrate | ACE2* | B38-CAP | Sequence |
|---|---|---|---|
Angiotensin I | + | + | DRVYIHPFH↓L |
Angiotensin 1–9 | − | + | DRVYIHPF↓H |
Angiotensin II | + | + | DRVYIHP↓F |
Angiotensin 1–7 | − | − | DRVYIHP |
Apelin-13 | + | + | QRPRLSHKGPMP↓F |
Apelin-36 | + | + | …QRPRLSHKGPMP↓F |
des-Arg9-bradykinin | + | + | RPPGFSP↓F |
Lys-des-Arg9-bradykinin | + | + | KRPPGFSP↓F |
β-Casomorphin | + | + | YPFVEP↓I |
Dynorphin A 1–13 | + | + | YGGFLRRIRPKL↓K |
Ghrelin | + | + | …ESKKPPAKLQP↓R |
Neurotensin 1–8 | + | + | pE-LYENKP↓R |
