Fig. 3: Optimization of PCr CEST contrast in human skeletal muscle on a 3 T clinical scanner.
From: In vivo imaging of phosphocreatine with artificial neural networks
The Z spectra were fitted using a polynomial and Lorentzian line-shape fitting (PLOF) CEST method. The observed CEST signal (ΔZ) indicating the difference between CEST peak and fitted background at 2.5 ppm is used as the evaluation parameter. a–d Acquired data and fitted results of CEST experiments with fixed saturation length of 800 ms and four saturation powers. e, f Acquired data and fitted results of CEST experiments with fixed saturation power of 0.6 µT and different saturation lengths. h, i Quantitative analysis of ΔZ with different saturation powers and saturation lengths, respectively (n = 3 ROIs). Error bars show standard deviations in ROIs.
