Fig. 3: Effect of C₁₂-G⁺ on mitochondria in human fibroblasts.

a Mitochondria morphology in human skin fibroblasts (C109 cells), treated with the solvent (Control) and C₁₂-G⁺. Mitochondria were labeled using an antibody against ATP synthase B. Scale bar = 5 µm. b Sensitivity of mitochondria morphology to C₁₂-G⁺ in C109 cells (Human) and Z. tritici cells. See Table 1 for EC₅₀ values. c Ultrastructure of mitochondria in human fibroblasts, treated with the solvent (Control) and C₁₂-G⁺. Note swollen cristae in C₁₂-G⁺-treated C109 cells. Scale bar = 0.3 µm. See also Supplementary Fig. 3a. d Sensitivity of mitochondrial potential to C₁₂-G⁺ in C109 cells (Human) and Z. tritici cells. See Table 1 for EC₅₀ values and also Supplementary Fig. 3b. Values (b, d) are shown as mean ± SEM; sample size n is indicated in each panel. Non-linear regression curve was calculated as dose-response inhibition (four parameters) in Prism5. See Supplementary Table 7 for experimental conditions. All source data are provided as a Source Data file.