Fig. 3: Terc−/− mice under a chronic rapamycin treatment retain S6 phosphorylation in the liver.
From: The mTOR pathway is necessary for survival of mice with short telomeres
a, b Quantification (a) and representative images (b) of phosphorylated ribosomal protein S6 (pS6) expression in liver from rapamycin or control fed Terc+/+ and G2 Terc−/− mice at the endpoint. c Two to 6 months old Terc+/+ and G2 Terc−/− mice were fed rapamycin or control diet and sacrificed 2 months later. d–i IHC quantification (d, f, h) and representative images (e, g, i) of pS6 expression from sections of liver (d, e), skeletal muscle (f, g), and heart (h, i) of mice control and rapamycin treated for 2 months. a.u. arbitrary units. Scale bars, 100 μm. Error bars represent the SE. n = number of mice. Statistical significance was determined by one-way Anova with post hoc Tukey test. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; n.s. not significant. Source data are provided as a Source Data file.
