Fig. 7: Reduced survival in late generation Terc−/− S6K1−/− mice.
From: The mTOR pathway is necessary for survival of mice with short telomeres
Kaplan–Meier survival curves of S6k1+/+ Terc+/+, S6k1−/− Terc+/+, G1–G3 S6k1+/+ Terc−/−, and G1–G3 S6k1−/− Terc−/− mice. a Females; the percentage of increase in median survival of S6k1−/− Terc+/+ mice relative to that of S6k1+/+ Terc+/+ is indicated (green arrow); the percentage of decrease in median survival of G3 S6k1−/− Terc−/− mice relative to that of G3 S6k1+/+ Terc−/− is indicated (red arrow). b Males. c Both sexes; the percentage of decrease in median survival of G3 S6k1−/− Terc−/− mice relative to that of G3 S6k1+/+ Terc−/− is indicated (red arrow). n = number of mice. Statistical significance was determined by the log-rank test and by the Gehan–Breslow–Wilcoxon test. The p values are indicated. Source data are provided as a Source Data file.
