Table 2 Demographic and clinical characteristics of the Stanford ICU patients.
From: A generalizable 29-mRNA neural-network classifier for acute bacterial and viral infections
Noninfected | Bacterial infection (micro positive & consensus) | Viral infection | Noninfected (forced adjudication) | Bacterial infection (forced adjudication) | Fungal infection | Mixed Infection | P value | |
|---|---|---|---|---|---|---|---|---|
n | 25 | 70 | 14 | 26 | 12 | 2 | 14 | |
Age (years) | 61.6 (19.0) | 66.3 (17.0) | 57.4 (15.1) | 63.0 (16.3) | 71.7 (7.8) | 33.5 (0.7) | 64.9 (11.7) | 0.031 |
Female sex (%) | 11 (44.0) | 32 (45.7) | 5 (35.7) | 10 (38.5) | 6 (50.0) | 1 (50.0) | 7 (50.0) | 0.977 |
Self-identified race/ethnicity (%) | 0.25 | |||||||
White | 15 (60.0) | 46 (65.7) | 9 (64.3) | 15 (57.7) | 5 (41.7) | 0 (0.0) | 6 (42.9) | |
Black/African-American | 4 (16.0) | 1 (1.4) | 0 (0.0) | 2 (7.7) | 0 (0.0) | 0 (0.0) | 1 (7.1) | |
Asian | 1 (4.0) | 4 (5.7) | 1 (7.1) | 0 (0.0) | 1 (8.3) | 0 (0.0) | 2 (14.3) | |
Hispanic | 0 (0.0) | 2 (2.9) | 0 (0.0) | 1 (3.8) | 0 (0.0) | 0 (0.0) | 1 (7.1) | |
Native Hawaiian or Pacific Islander | 1 (4.0) | 3 (4.3) | 0 (0.0) | 2 (7.7) | 2 (16.7) | 0 (0.0) | 2 (14.3) | |
Other | 1 (4.0) | 0 (0.0) | 1 (7.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (7.1) | |
Unknown | 3 (12.0) | 14 (20.0) | 3 (21.4) | 6 (23.1) | 4 (33.3) | 2 (100.0) | 1 (7.1) | |
ED admission (%) | 20 (80.0) | 53 (75.7) | 11 (78.6) | 17 (65.4) | 11 (91.7) | 1 (50.0) | 11 (78.6) | 0.637 |
OR admission (%) | 1 (6.2) | 2 (5.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0.941 |
APACHE II score | 21.88 (10.11) | 25.33 (9.62) | 25.64 (6.44) | 25.81 (9.57) | 31.91 (10.36) | 19.00 (2.83) | 30.00 (6.60) | 0.043 |
Shock (%) | 5 (20.0) | 53 (75.7) | 9 (64.3) | 15 (57.7) | 11 (100.0) | 0 (0.0) | 9 (64.3) | <0.001 |
Immuno-compromised (%) | 7 (28.0) | 19 (27.1) | 5 (35.7) | 5 (19.2) | 1 (8.3) | 2 (100.0) | 8 (57.1) | 0.025 |
On IV antibiotics at study enrollment (%) | 19 (76.0) | 70 (100.0) | 14 (100.0) | 25 (96.2) | 12 (100.0) | 2 (100.0) | 14 (100.0) | <0.001 |
Mortality at 60 days (%) | 5 (20.0) | 12 (17.1) | 1 (7.1) | 6 (23.1) | 3 (25.0) | 1 (50.0) | 7 (50.0) | 0.11 |
Procalcitonin (ng/ml - Tricore) | 1.74 (2.96) | 25.49 (29.65) | 5.75 (15.75) | 8.08 (20.79) | 24.87 (42.88) | 2.15 (1.27) | 21.40 (29.26) | 0.002 |
C-reactive protein (mg/dl - Tricore) | 10.11 (6.48) | 15.20 (4.70) | 11.13 (6.33) | 10.76 (6.38) | 13.73 (4.20) | 11.15 (0.35) | 16.50 (4.27) | <0.001 |
