Table 1 Twenty eight novel loci identified by the cross-ancestry meta-analysis.

From: Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

SNP

Chr

BP

Effect

Other

Locus

Asian-specific

European-specific

Cross-ancestry

I2, %

P het

EAF

OR (95% CI)

P

EAF

OR (95% CI)

P

EAF

OR (95% CI)

P

rs72906468

1

17772093

A

T

1p36.13

0.68

1.06 (1.03–1.09)

1.5 × 10−4

0.77

1.04 (1.02–1.05)

2.2 × 10−6

0.76

1.04 (1.03–1.05)

4.0 × 10−9

0

0.59

rs3790585

1

46023356

A

T

1p34.1

0.69

1.05 (1.02–1.08)

1.4 × 10−3

0.85

1.04 (1.03–1.06)

8.8 × 10−7

0.81

1.04 (1.03–1.06)

5.3 × 10−9

5.1

0.39

rs2758598

1

156194339

A

G

1q22

0.16

1.07 (1.03–1.11)

1.8 × 10−4

0.33

1.03 (1.02–1.05)

8.4 × 10−7

0.31

1.04 (1.02–1.05)

3.6 × 10−9

57.7

0.01

rs6756513

2

70172587

A

G

2p13.3

0.30

0.96 (0.94–0.99)

0.01

0.29

0.96 (0.95–0.98)

4.2 × 10−7

0.29

0.96 (0.95–0.98)

1.5 × 10−8

0

0.80

rs73006998

3

150464271

A

G

3q25.1

0.33

0.92 (0.89–0.94)

2.4 × 10−9

0.03

0.94 (0.91–0.98)

5.8 × 10−3

0.22

0.93 (0.90–0.95)

1.1 × 10−10

10.0

0.35

rs11281251

3

156519412

T

TTGTGAC

3q25.31

0.18

0.94 (0.90–0.98)

1.9 × 10−3

0.39

0.97 (0.96–0.98)

4.2 × 10−7

0.37

0.97 (0.95–0.98)

8.4 × 10−9

24.5

0.24

rs11944638

4

48227719

T

C

4p11

0.74

1.08 (1.04–1.11)

6.0 × 10−6

0.93

1.05 (1.02–1.08)

3.1 × 10−4

0.85

1.06 (1.04–1.08)

1.6 × 10−8

0

0.83

rs11947923

4

53911337

T

C

4q12

0.28

0.96 (0.93–0.99)

0.01

0.37

0.97 (0.96–0.98)

1.0 × 10−6

0.36

0.97 (0.96–0.98)

4.5 × 10−8

0

0.76

rs6555134

5

2776483

T

C

5p15.33

0.26

0.95 (0.92–0.98)

1.5 × 10−3

0.58

0.97 (0.96–0.98)

3.6 × 10−7

0.54

0.97 (0.95–0.98)

2.9 × 10−9

0

0.77

rs7765429

6

21904169

T

C

6p22.3

0.89

0.94 (0.90–0.98)

6.8 × 10−3

0.46

0.97 (0.96–0.98)

3.3 × 10−7

0.49

0.97 (0.96–0.98)

1.7 × 10−8

6.4

0.38

rs7768862

6

85088846

A

T

6q14.3

0.29

0.95 (0.92–0.97)

1.7 × 10−4

0.51

0.97 (0.96–0.98)

6.4 × 10−6

0.48

0.97 (0.96–0.98)

2.0 × 10−8

0.0

0.52

rs6940159

6

170332621

T

C

6q27

0.82

0.94 (0.91–0.97)

4.6 × 10−4

0.38

0.97 (0.96–0.98)

2.7 × 10−7

0.43

0.96 (0.95–0.98)

1.7 × 10−9

7.7

0.37

rs144145984

8

23644003

CT

C

8p21.2

0.43

0.96 (0.94–0.99)

3.4 × 10−3

0.57

0.97 (0.96–0.98)

1.7 × 10−6

0.55

0.97 (0.96–0.98)

2.4 × 10−8

0

0.56

rs2849506

8

101329134

C

G

8q22.2

0.49

0.96 (0.93–0.98)

9.9 × 10−4

0.40

0.97 (0.96–0.98)

7.5 × 10−6

0.41

0.97 (0.96–0.98)

4.7 × 10−8

0

0.94

rs142360995

8

118205719

A

G

8q24.11

0.09

1.13 (1.07–1.18)

4.1 × 10−6

0.20

1.03 (1.02–1.05)

1.0 × 10−5

0.19

1.04 (1.03–1.06)

3.0 × 10−8

64.0

0.003

rs10820600

9

106856692

T

C

9q31.1

0.82

0.95 (0.92–0.99)

7.6 × 10−3

0.44

0.97 (0.96–0.98)

1.8 × 10−7

0.48

0.97 (0.96–0.98)

5.7 × 10−9

29.1

0.19

rs541079479

10

22861533

CA

C

10p12.2

0.13

1.06 (1.01–1.11)

0.01

0.42

1.03 (1.02–1.05)

7.0 × 10−7

0.39

1.03 (1.02–1.05)

4.9 × 10−8

0

0.83

rs2901157

10

119262365

A

G

10q26.11

0.75

1.06 (1.03–1.09)

4.2 × 10−4

0.89

1.05 (1.03–1.07)

2.3 × 10−6

0.85

1.05 (1.03–1.07)

4.0 × 10−9

0

1

rs10838267

11

44368892

A

G

11p11.2

0.33

1.06 (1.03–1.09)

8.2 × 10−5

0.54

1.03 (1.02–1.05)

3.2 × 10−7

0.51

1.04 (1.03–1.05)

4.2 × 10−10

11.9

0.34

rs78588049

12

69180907

A

ATTTT

12q15

0.15

0.93 (0.90–0.97)

7.5 × 10−4

0.20

0.96 (0.95–0.98)

3.3 × 10−6

0.19

0.96 (0.95–0.97)

3.0 × 10−8

4.0

0.40

rs855596

12

103045519

T

C

12q23.2

0.07

0.90 (0.86–0.95)

8.3 × 10−5

0.03

0.92 (0.89–0.96)

1.9 × 10−5

0.04

0.91 (0.89–0.94)

7.5 × 10−9

5.0

0.39

rs9316500

13

51094114

T

G

13q14.3

0.36

1.05 (1.02–1.08)

4.0 × 10−4

0.71

1.03 (1.02–1.05)

6.7 × 10−6

0.64

1.03 (1.02–1.05)

2.1 × 10−8

5.7

0.39

rs75004998

14

77517786

A

G

14q24.3

0.51

0.96 (0.94–0.99)

7.8 × 10−3

0.33

0.97 (0.96–0.98)

1.8 × 10−6

0.36

0.97 (0.96–0.98)

4.9 × 10−8

0

0.92

rs8027365

15

75808740

A

C

15q24.2

0.62

1.05 (1.02–1.08)

1.3 × 10−3

0.73

1.04 (1.02–1.05)

9.7 × 10−8

0.71

1.04 (1.03–1.05)

4.6 × 10−10

8.4

0.37

rs76535198

16

71892498

A

C

16q22.2

0.72

1.08 (1.04–1.11)

1.2 × 10−6

0.86

1.04 (1.03–1.06)

2.3 × 10−6

0.83

1.05 (1.04–1.07)

5.4 × 10−11

0.7

0.43

rs12481286

20

52287610

T

G

20q13.2

0.31

1.05 (1.01–1.08)

3.5 × 10−3

0.24

1.04 (1.03–1.06)

1.0 × 10−7

0.26

1.04 (1.03–1.06)

1.1 × 10−9

0

0.52

rs35418111

21

47856670

A

G

21q22.3

0.20

1.07 (1.04–1.11)

3.2 × 10−5

0.07

1.06 (1.04–1.09)

6.1 × 10−7

0.12

1.07 (1.05–1.09)

1.1 × 10−10

0

0.97

rs34331122

22

19762428

CTT

C

22q11.21

0.56

0.94 (0.91–0.97)

3.7 × 10−5

0.46

0.97 (0.96–0.98)

7.2 × 10−6

0.47

0.97 (0.96–0.98)

1.0 × 10−8

2.2

0.41

  1. BP base position, NCBI build 37, EAF effect allele frequency, OR odds ratio, CI confidence interval.
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