Table 3 Eight novel breast cancer risk-associated SNPs located within previously known loci in Asians: a conditional analysis.
SNP | Chr | BP | Effect | Other | Reported | Locus | Nearest gene | EAF | OR (95% CI) | P | I2, % | Phet |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
rs112776581 | 5 | 56054333 | T | TA | rs62355902 | 5q11.2 | LOC105378979 | 0.11 | 1.21 (1.15–1.27) | 3.5 × 10−14 | 0 | 0.70 |
rs2941741 | 6 | 152008982 | A | G | rs9397437,rs2747652 | 6q25.1 | ESR1 | 0.13 | 1.13 (1.08–1.17) | 8.2 × 10−10 | 0 | 0.62 |
rs974336 | 9 | 22006348 | T | C | rs1011970 | 9p21.3 | CDKN2B | 0.22 | 1.10 (1.06–1.13) | 5.9 × 10−9 | 24.6 | 0.22 |
rs78053936 | 10 | 64300331 | A | C | rs10822013,rs10995201 | 10q21.2 | ZNF365 | 0.80 | 1.11 (1.07–1.15) | 1.7 × 10−8 | 20.4 | 0.27 |
rs61929345 | 12 | 116001403 | T | G | rs1292011 | 12q24.21 | LOC105370003 | 0.16 | 1.11 (1.07–1.15) | 4.9 × 10−8 | 8.8 | 0.36 |
rs3803661 | 16 | 52586477 | A | G | rs4784227 | 16q12.1 | CASC16 | 0.63 | 1.08 (1.05–1.12) | 3.7 × 10−8 | 0 | 0.61 |
rs12455117 | 18 | 42884026 | A | T | rs6507583 | 18q12.3 | SLC14A2 | 0.68 | 1.09 (1.06–1.12) | 1.7 × 10−8 | 0 | 0.74 |
rs2823126 | 21 | 16561704 | A | G | rs2823093 | 21q21.1 | NRIP1 | 0.28 | 0.90 (0.88–0.93) | 1.1 × 10−10 | 39.5 | 0.12 |
