Fig. 2: Venetoclax-sensitive MM exhibits reduced Complex I and Complex II activity. | Nature Communications

Fig. 2: Venetoclax-sensitive MM exhibits reduced Complex I and Complex II activity.

From: Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma

Fig. 2

a Complex I activity was assessed in the indicated lines as described in Materials and Methods. b SDH activity and c SQR activity were assessed in gently permeabilized whole cells supplemented with succinate and Complex I, III and IV inhibitors. d CS activity was assessed as described in Materials and Methods. Complex I, SQR and SDH activity were significantly different in sensitive vs. resistant lines (p values 0.008, 0.0007 and 0.0007 respectively) while CS activity did not differ significantly (p value = 0.2824). n = 3 independent experiments. Data are presented as mean values ± SEM. p values are calculated using a two-tailed Mann−Whitney test. Venetoclax-resistant lines have been shown in green and venetoclax-sensitive lines have been shown in purple bars in (a−d). Source data are provided as a source data file.

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