Fig. 3: Summary data-based Mendelian randomization analyses at the SLC7A11 locus. | Nature Communications

Fig. 3: Summary data-based Mendelian randomization analyses at the SLC7A11 locus.

From: Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease

Fig. 3

a The uppermost plot shows −log10(P values) of SNPs from the PDWBS GWAS meta-analysis63. The red diamonds and blue circles represent −log10(P values) from SMR tests for association of gene expression and DNA methylation probes with PD, respectively. Neither SLC7A11 nor cg06690548 show evidence for a genetic association with PD. The middle plot shows −log10(P values) of the SNP associations for gene expression probe ENSG00000151012 (tagging SLC7A11) from the Brain-eMeta eQTL study57. The bottom plot shows −log10(P values) of the SNP associations for DNA methylation probe cg06690548 from the Brain-mMeta mQTL study57. b Relationship between effect sizes of mQTLs for cg06690548 from the Brain-mMeta mQTL study57 and the corresponding effect sizes for gene expression probe ENSG00000151012 from the Brain-eMeta eQTL study57 (SMR, p = 3.59  ×  10−03). The red triangle shows the top cis-mQTL, blue circles indicate cis-mQTLs. Error bars show the standard errors of the SNP effects.

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