Fig. 7: Model of hRpn10 RAZUL recruitment of E6AP to the 26S proteasome.
From: Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10
Proteasome substrate receptors Rpn1, Rpn10, and Rpn13 recognize ubiquitin chains (yellow) through their T1 site (blue), UIM region (blue), and Pru domain (blue), respectively. The Rpn10 C-terminal RAZUL is intrinsically disordered (left panel), but folds to form a 4-helix bundle with the AZUL domain of E3 ligase E6AP (green), thus recruiting E6AP to the proteasome (right panel). Zn, light blue.
