Fig. 6: The SPRY domain binding interface.
From: TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid
a Probability for residues on the CA domain to form contacts with TRIM5α calculated from both simulation (CG) and experimental cryo-ET density maps (Expt). b The simulated contact probability is shown in a 3D map overlaid with the atomic structure of the CA domain and colored by regions from highest contact probability (blue) to lowest contact probability (red). c The CG structure of the CA tubule with highest contact probability (pc = 0.10) in blue and regions of lowest probability colored in red (pc = 0.0) sub-divided in three sections. The leftmost section shows the contact probability across the tubule; the middle section shows the probability at positions for which the SPRY domain bound during a CG assembly simulation; the rightmost section shows the binding positions of the SPRY domains. Source data are provided as a Source Data file.
